| Identification | Back Directory | [Name]
glycyl-prolyl-glutamic acid | [CAS]
32302-76-4 | [Synonyms]
SC-252859
Glypromate
Gly-Pro-Glu >=98% (HPLC)
glycyl-prolyl-glutamic acid
Glycyl-L-prolyl-L-glutamic acid
L-GlutaMic acid, glycyl-L-prolyl-
glycyl-prolyl-glutamic acid USP/EP/BP | [Molecular Formula]
C12H19N3O6 | [MDL Number]
MFCD00677175 | [MOL File]
32302-76-4.mol | [Molecular Weight]
301.3 |
| Chemical Properties | Back Directory | [Boiling point ]
675.7±55.0 °C(Predicted) | [density ]
1.431±0.06 g/cm3(Predicted) | [storage temp. ]
Store at 0°C | [solubility ]
H2O: >5mg/mL | [form ]
white powder | [pka]
3.51±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Definition]
ChEBI: Gly-Pro-Glu is an oligopeptide. | [Biological Activity]
Gly-Pro-Glu (GPE) is a neuroactive peptide and prevents the binding of glutamate to N-methyl-D-aspartate (NMDA) receptor. It positively regulates the potassium-mediated release of acetylcholine from r at cortical slices. Thusit is involved in the control of brain function. In vitro studies show th at this peptide confers neuroprotection to CA1-2 hippocampal neurons against excitotoxic insult.''Gly-Pro-Glu is a neuroprotective compound and the N-terminal tripeptide of IGF-1. Gly-Pro-Glu is neuroprotective after central administration in animal models of neurodegenerative processessuch as Huntington′sParkinson′sAlzheimer′s diseasesand varies acute brain injury animal models. The neuroprotective activity is not related to its affinity to glutamate receptor. Findings indicate th at GPE mimics insulin-like growth factor I effects on the somatostatin system through a mechanism independen |
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BOC Sciences
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https://www.bocsci.com |
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