| Chemical Properties | Back Directory | [Boiling point ]
458.0±45.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: Soluble; Ethanol: 1 mg/ml; Methanol: Soluble | [form ]
A solid | [pka]
12.86±0.40(Predicted) |
| Hazard Information | Back Directory | [Description]
Quinolactactin A is a quinolone fungal metabolite originally isolated from Penicillium. It inhibits TNF production induced by LPS in murine peritoneal macrophages (IC50 = 12.2 μg/ml). It is not active against a variety of bacteria, fungi, and yeasts. Quinolactacin A is a mixture of quinolactacin A1 and A2. | [Uses]
(S)-Quinolactacine A is a quinolone inhibitor that targets TNF production[1]. | [References]
[1] Tatsuya Sasaki, et al. Biosynthesis of quinolactacin A, a TNF production inhibitor. J Antibiot (Tokyo). 2006 Jul;59(7):418-27. DOI:10.1038/ja.2006.59 |
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