| Identification | Back Directory | [Name]
JNJ0966 | [CAS]
315705-75-0 | [Synonyms]
JNJ0966
JNJ0966;JNJ 0966;JNJ-0966;315705-75-0
N-[2-[(2-Methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]acetamide
Acetamide, N-[2-[(2-methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]- | [Molecular Formula]
C16H16N4O2S2 | [MDL Number]
MFCD02045222 | [MOL File]
315705-75-0.mol | [Molecular Weight]
360.45 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:63.34(Max Conc. mg/mL);175.72(Max Conc. mM) | [form ]
A crystalline solid | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Uses]
JNJ0966, is a highly selective MMP-9 zymogen inhibitor. | [Biological Activity]
JNJ0966 is a potent and highly selective inhibitor of matrix metalloproteinase-9 (MMP-9) zymogen activation. It appears th at JNJ0966 binds to a structural pocket in proximity to the MMP-9 zymogen cleavage site near Arg-106. JNJ0966 reduces disease severity in in a mouse experimental autoimmune encephalomyelitis (EAE) model. JNJ0966 does not inhibit activation of MMP-2 zymogenand has no effect on MMP-1MMP-2MMP-3MMP-9 or MMP-14 catalytic activity. | [storage]
Store at -20°C |
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