| Identification | Back Directory | [Name]
FLI-06 | [CAS]
313967-18-9 | [Synonyms]
I-06
FLI-06
CS-1434
FLI-06 |FLI06
FLI-06, 98%, a notch signaling and the early secretory pathway inhibitor
Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate
1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester
3-QUINOLINECARBOXYLIC ACID, 1,4,5,6,7,8-HEXAHYDRO-2,7,7-TRIMETHYL-4-(4-NITROPHENYL)-5-OXO-, CYCLOHEXYL ESTER
1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester FLI-06 | [Molecular Formula]
C25H30N2O5 | [MDL Number]
MFCD00330996 | [MOL File]
313967-18-9.mol | [Molecular Weight]
438.52 |
| Chemical Properties | Back Directory | [Melting point ]
199-202oC | [Boiling point ]
597.5±50.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble5mg/mL, clear (warmed) | [form ]
powder | [pka]
0.78±0.70(Predicted) | [color ]
white to beige | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week. |
| Hazard Information | Back Directory | [Description]
FLI-06 (313967-18-9) was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It was found to disrupt the Golgi apparatus in a manner distinct from that of brefeldin A. It inhibited general secretion at a step before exit from the ER which was accompanied by a tubule-to-sheet morphological transition of the ER. Thus FLI-06 is the first small molecule acting at such an early stage in secretory traffic.1 | [Uses]
FLI-06 is a novel inhibitor of Notch signalling and the early secretory pathway. | [References]
1) Kramer?et al., (2013),?Small molecules intercept Notch signaling and the early secretory pathway; Nat. Chem. Biol.?9 731 |
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