| Identification | Back Directory | [Name]
PD-118057 | [CAS]
313674-97-4 | [Synonyms]
PD-118057 >=98% (HPLC), solid
Benzoic acid, 2-[[4-[2-(3,4-dichlorophenyl)ethyl]phenyl]amino]- | [Molecular Formula]
C21H17Cl2NO2 | [MDL Number]
MFCD08705328 | [MOL File]
313674-97-4.mol | [Molecular Weight]
386.27 |
| Chemical Properties | Back Directory | [Boiling point ]
527.0±50.0 °C(Predicted) | [density ]
1.353±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: soluble9mg/mL | [form ]
solid | [pka]
3.70±0.36(Predicted) | [color ]
light yellow |
| Hazard Information | Back Directory | [Biological Activity]
PD-118057 is an activator of ether-a-go-go-related (hERG) potassium channel. PD-118057 is a second identified hERG channel activatora representative in the series of structural analogs; PD-118057 at 10 μM leads to a 111% current increase in rabbit ventricular wedge (in comparison RPR260243 leads to only a 15% increase at the same concentration);PD-118057unlike RPR260243does not have a major effect on gating or kinetic properties of this channel. PD-118057prevents and reverses QT interval prolongation; Compounds such as PD-118057 may offer new approach in the treatment of delayed repolarization conditionswhich occur in inherited or acquired long QT syndrome and congestive heart failure |
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Energy Chemical
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