| Identification | Back Directory | [Name]
2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide | [CAS]
313254-51-2 | [Synonyms]
ICA-121431
ICA-121431 >=98% (HPLC)
ICA-121431;ICA 121431;ICA121431
2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl
2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide
2,2-DIPHENYL-N-(4-(N-THIAZOL-2-YLSULFAMOYL)PHENYL) ACETAMIDE
α-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-benzeneacetamide
Benzeneacetamide, α-phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-
alpha-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]benzeneacetamide | [EINECS(EC#)]
809-095-0 | [Molecular Formula]
C23H19N3O3S2 | [MDL Number]
MFCD00992334 | [MOL File]
313254-51-2.mol | [Molecular Weight]
449.55 |
| Chemical Properties | Back Directory | [density ]
1.409±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: soluble20mg/mL, clear | [form ]
powder | [pka]
7.03±0.10(Predicted) | [color ]
white to beige | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | [InChIKey]
URSQNPPONHUJDL-UHFFFAOYSA-N |
| Hazard Information | Back Directory | [Description]
ICA 121431 is a voltage-gated sodium channel (Nav) blocker that selectively blocks Nav1.1 and Nav1.3 over Nav1.4, and Nav1.5-1.8 channels (IC50s = <20, 19, 240, and >10,000 nM, respectively).1 It induces a concentration-dependent hyperpolarizing shift in voltage dependence of inactivation of Nav1.3 channels at a concentration 1 μM but has no effect on resting channels. Substitution of the Nav1.3 domain IV voltage-sensor domain (VSD4) with the Nav1.5 VSD4 reduces ICA 121431 potency by approximately 500-fold. | [Uses]
ICA 121431 is a voltage-gated sodium (Nav) channel inhibitor. | [storage]
Store at -20°C | [References]
McCormack et al. (2013), Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels; Proc. Natl. Acad. Sci. USA 110 E2724
Ostenn et al. (2017), Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes; Proc. Natl. Acad. Sci. USA 114 6836 |
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D&C Chemicals
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