| Identification | Back Directory | [Name]
Hygromycin B | [CAS]
31282-04-9 | [Synonyms]
950U/MG
Hygromix
Hygrovetin
hygromix-8
hygrovetine
hydromycinb
hygromix2.4
antihelmycin
Hyaromycin B
Hygromycin B
HYGROGOLD(TM)
HYGROMYCIN B 85+%
HYGROMYCIN B 98+%
O-6-Amino-6-deoxy-
Hygromycin Solution
HYGROMYCIN B HYDRATE
Hygromycin B, powder
HygroMycin B, OMniPur(R)
Hygromycin B, PBS solution
Hygromycin B Solution, 100ppm
Hygromycin B solution,1000ppm
hygromycin B aqueous solution
HYGROMYCIN B, STREPTOMYCES SPECIES
hygromycin B plant cell culture tested
HYGROMYCIN B, STREPTOMYCES HYGROSCOPICUS
hygromycin B from streptomyces*hygroscopicus
HygromycinB,HighPurity,Solid,CellCultureTested
Hygromycin B solution Streptomyces hygroscopicus
HYGROMYCIN B FROM STREPTOMYCES*HYGROSCOP ICUS, CELL
HYGROMYCIN B FROM STREPTOMYCES*HYGROSCOP ICUS LYOPHI
hygromycin B solution from streptomyces hygroscopicus
HYGROMYCIN B, HIGH PURITY, POWDER, CELL CULTURE TESTED
)-o-beta-d-talopyranosyl-(1-5)-2-deoxy-n-(sup3)-methyl-
HygromycinB,Streptomyceshygroscopicus,HighPurity,inDIWater
HygromycinB,Streptomyceshygroscopicus,ConcentratedSolution
HYGROMYCIN B, HIGH PURITY, IN DI WATER, CELL CULTURE TESTED
HygromycinB,Streptomyceshygroscopicus,HighPurity,inPBSBuffer
HYGROMYCIN B, HIGH PURITY, IN PBS BUFFER, CELL CULTURE TESTED
HYGROMYCIN B, HIGH PURITY, IN HEPES BUFFER, CELL CULTURE TESTED
Hygromycin B from Streptomyces hygroscopicus Vetec(TM) reagent grade
Hygromycin B from Streptomyces hygroscopicus from Streptomyces hygrosco
5-O-(2,3-O-(6-Amino-6-desoxyheptapyranosyliden)-beta-D-talopyranosyl)-desoxy-N'-methyl-D-streptamin
O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-β-D-talopyranosyl(1-5)-2-deoxy-N3-methyl-D-streptamine
O-6-Amino-6-deoxy-l-glycero-d-galactoheptapyranosylidene-(1,2,3)-o-beta-d-talopyranosyl-(1,5)-2-deoxy-n3-methyl-d-streptamine
D-Streptamine, O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1→2-3)-O-β-D-talopyranosyl-(1→5)-2-deoxy-N3-methyl-
O-6-AMINO-6-DEOXY-L-GLYCERO-D-GALACTO-HEPTOPYRANOSYLIDENE-(1-2-3)-O-BETA-D-TALOPYRANOSYL(1-5)-2-DEOXY-N3-METHYL-D-STREPTAMINE
O-6-AMINO-6-DEOXY-L-GLYCERO-D-GALACTOHEPTAPYRANOSYLIDENE-(1,2,3)-O-BETA-D-TALOPYRANOSYL-(1,5)-2-DEOXY-N3-METHYL-D-STREPTAMINE
o-6-amino-6-deoxy-l-glycero-d-galacto-heptopyranosylidene-(1-2-3)-o-beta-d-talopyranosyl-(1-5)-2-deoxy-n3-methyl-d-streptamine
O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-o-beta-D-talopyranosyl-(1-5)-2-deoxy-N3-methyl-D-streptamine
D-Streptamine, O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1?2-3)-O-.beta.-D-talopyranosyl-(1?5)-2-deoxy-N3-methyl-
Hygromycin B
O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-o-beta-D-talopyranosyl-(1-5)-2-deoxy-N3-methyl-D-streptamine | [EINECS(EC#)]
250-545-5 | [Molecular Formula]
C20H37N3O13 | [MDL Number]
MFCD06795480 | [MOL File]
31282-04-9.mol | [Molecular Weight]
527.52 |
| Chemical Properties | Back Directory | [Melting point ]
160-180°C | [alpha ]
D20 +20.2° (c = 1 in water) | [Boiling point ]
608.13°C (rough estimate) | [density ]
1.4252 (rough estimate) | [refractive index ]
1.6300 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
H2O: 50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 30 days.
| [form ]
powder
| [pka]
7.1, 8.8(at 25℃) | [color ]
faintly brown to brown | [PH]
pH (25g/l, 25℃ ) : 9.5～12.5 | [biological source]
Streptomyces hygroscopicus | [Water Solubility ]
Miscible with water, methanol, buffer solution and ethanol. Immiscible with less polar solvents. | [Merck ]
13,4878 | [BRN ]
6755837 | [Stability:]
Hygroscopic | [EPA Substance Registry System]
Hygromycin B (31282-04-9) |
| Hazard Information | Back Directory | [Usage]
antibacterial, anthelmintic; LD50 ip (rat) 63mg/Kg | [Usage]
Hygromycin B is a trisaccharide aminoglycoside with a terminal cyclitol produced by Streptomyces hygroscopicus, reported by researchers at Eli Lily in the early 1950s. Hygromycin B belongs to the destomycin family of aminoglycosides which contain a unique cyclic structure linking the terminal saccharide. Hygromycin B exhibits broad spectrum antibiotic and anthelmintic activity, and is used as a feed additive for swine and poultry. Hygromycin B inhibits polypeptide synthesis by binding peptidyl-tRNA and preventing translocation by Elongation Factor 2. | [Usage]
Hygromycin B is an aminoglycoside and a selective antibiotic agent for the hph gene. Hygromycin B inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S rib
osome | [Usage]
Hygromycin B, a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome | [General Description]
Amorphous solid or tan powder. | [Air & Water Reactions]
Water soluble. | [Reactivity Profile]
Weakly basic. | [Fire Hazard]
Flash point data for Hygromycin B are not available; however Hygromycin B is probably combustible. | [Description]
Hygromycin B is an aminoglycoside antibiotic that has been found in S. hygroscopicus.1,2 It is active against E. coli (MIC = 150 μg/ml) and cytotoxic to both prokaryotic and eukaryotic cells via inhibition of protein synthesis.3,4,5 Hygromycin B has commonly been used in molecular and cell biology applications to select for transformed cells expressing the E. coli hygromycin resistance genes hyg or hph.4,5 | [Chemical Properties]
White to off-white lyophilized powder | [Uses]
antibacterial, anthelmintic; LD50 ip (rat) 63mg/Kg | [Uses]
Hygromycin B is a trisaccharide aminoglycoside with a terminal cyclitol produced by Streptomyces hygroscopicus, reported by researchers at Eli Lily in the early 1950s. Hygromycin B belongs to the destomycin family of aminoglycosides which contain a unique cyclic structure linking the terminal saccharide. Hygromycin B exhibits broad spectrum antibiotic and anthelmintic activity, and is used as a feed additive for swine and poultry. Hygromycin B inhibits polypeptide synthesis by binding peptidyl-tRNA and preventing translocation by Elongation Factor 2. | [Uses]
Hygromycin B is an aminoglycoside and a selective antibiotic agent for the hph gene. Hygromycin B inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S rib
osome | [Uses]
Hygromycin B, a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome | [Application]
Hygromycin B was found in the culture broth of Streptomyces hygroscopicus by Lilly Research Laboratories in 1953, as a mixture with hygromycin A. It showed activity against a variety of gram-positive and gram-negative bacteria as well as fungi. Hygromycin B has been used for therapy of helminthic infections in swine and poultry. | [Biochem/physiol Actions]
Mode of Action: The product acts by inhibiting protein synthesis by inducing the misreading of the m-RNA template in the prokaryote, with the potency to inhibit translation. Antimicrobial Spectrum: Hygromycin B acts against bacteria, fungi and higher eukaryotic cells. | [storage]
+4°C | [References]
[1] brodersen de, clemons wm jr, carter ap, et al. the structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin b on the 30s ribosomal subunit. cell, 2000, 103 (7): 1143-1154.
[2] ganoza mc, kiel mc. a ribosomal atpase is a target for hygromycin b inhibition on escherichia coli ribosomes. antimicrob agents chemother, 2001, 45 (10): 2813-2819. |
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