| Identification | Back Directory | [Name]
L-Valine, N-(3-methoxy-1,3-dioxopropyl)-, methyl ester | [CAS]
308277-46-5 | [Synonyms]
EX-A5758
L-Valine, N-(3-methoxy-1,3-dioxopropyl)-, methyl ester | [Molecular Formula]
C10H17NO5 | [MOL File]
308277-46-5.mol | [Molecular Weight]
231.25 |
| Chemical Properties | Back Directory | [Boiling point ]
350.1±22.0 °C(Predicted) | [density ]
1.115±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 46 mg/mL (198.92 mM);Ethanol: 46 mg/mL (198.92 mM) | [form ]
Solid | [pka]
12.22±0.46(Predicted) | [color ]
Off-white to light yellow | [Water Solubility ]
Water: 46 mg/mL (198.92 mM) | [InChI]
InChI=1S/C10H17NO5/c1-6(2)9(10(14)16-4)11-7(12)5-8(13)15-3/h6,9H,5H2,1-4H3,(H,11,12)/t9-/m0/s1 | [InChIKey]
BWPKYDAJBOUZDX-VIFPVBQESA-N | [SMILES]
C(OC)(=O)[C@H](C(C)C)NC(=O)CC(OC)=O |
| Hazard Information | Back Directory | [Biological Activity]
ZLc-002 is a selective inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain. | [Biological Functions]
ZLc002, a putative small-molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability. It could disrupt binding between nNOS and NOS1AP using ex-vivo, in vitro, and purified recombinant systems. In vitro, ZLc002 reduced coimmunoprecipitation of full-length NOS1AP and nNOS in cultured neurons and HEK293T cells co-expressing full-length nNOS and NOS1AP[1]. | [References]
[1] Lee WH, et al. Mol Pain. 2018 Jan-Dec;14:1744806918801224. |
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cjbscvictory
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13348960310 13348960310 |
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https://www.weikeqi-biotech.com/ |
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