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ChemicalBook--->CAS DataBase List--->304481-72-9

304481-72-9

304481-72-9 Structure

304481-72-9 Structure
IdentificationBack Directory
[Name]

2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide
[CAS]

304481-72-9
[Synonyms]

PKUMDL WQ 2101
PKUMDL-WQ-2101 >=98% (HPLC)
Benzoic acid, 2,4-dihydroxy-, 2-[(2-hydroxy-5-nitrophenyl)methylene]hydrazide
[Molecular Formula]

C14H11N3O6
[MDL Number]

MFCD00589939
[MOL File]

304481-72-9.mol
[Molecular Weight]

317.25
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[color ]

Light yellow to yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P264-P271-P280-P302+P352-P304+P340-P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501
Hazard InformationBack Directory
[Biological Activity]

PKUMDL-WQ-2101 is a potent and selective non-NAD+-competing allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) th at selectively inhibits serine synthesis in cancer cells. PKUMDL-WQ-2101 binds to allosteric site Iwhich is located close to active site. PKUMDL-WQ-2101 inhibits tumor growth of MDA-MB-468 xenografts in mice.
[storage]

Store at -20°C
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