| Identification | Back Directory | [Name]
L-Acetylcarnitine | [CAS]
3040-38-8 | [Synonyms]
C2 carnitine
L-Acetylcarnitine
Actyl-L-carnitine
L-O-Acetylcarnitine
(R)-Acetylcarnitine
Levocarnitine acetyl
O-acetyl-L-carnitine
(3S)-3-acetyloxy-4-trimethylammonio-butanoate
(3R)-3-(Acetyloxy)-4-(trimethylammonio)butanoate
(-)-[(R)-3-Carboxylato-2-acetoxypropyl]trimethylaminium
(R)-3-Carboxylato-2-acetoxy-N,N,N-trimethyl-1-propanaminium
1-PropanaMiniuM,2-(acetyloxy)-3-carboxy-N,N,N-triMethyl-, inner salt, (2R)- | [Molecular Formula]
C9H17NO4 | [MOL File]
3040-38-8.mol | [Molecular Weight]
203.24 |
| Hazard Information | Back Directory | [Description]
L-Acetylcarnitine is a endogenous substance, synthesized in the mitochondria, that increases cellular oxidative metabolism and cholinergic activity. It has a good penetration in the CNS when administered orally and intravenously, and no side effects have been observed.
L-Acetylcarnitine has a large variety of interesting pharmacological properties:
It is a cholinergic agent because it promotes the synthesis and freeing of acetylcholine.
It reduces oxidation processes, thus reducing lipofuscin deposits in the brain.
It acts on the hypothalamic-hypophyseal-adrenal axis, antagonizing the existing downregulation (Carta and Calvani 1991).
In a 1-year study of 130 patients with AD (63 in treatment with L-acetylcarnitine and 67 with placebo), an improvement in the cognitive decline measured through neuropsychiatric batteries was observed (Spagnoli et al. 1991). | [Uses]
Acetylcarnitine may be a useful for treatment of male infertility caused by low quantities of immobile sperm.
Acetyl-L-carnitine (ALC) is produced naturally in humans, and can be found in the brain, liver, and kidneys. ALC is also available as a dietary supplement. ALC has been studied for its potential use in slowing the progression of age-related memory loss and Alzheimer’s disease. ALC may also have a potential use in the treatment of neuropathy (nerve pain) associated with diabetes and HIV disease. | [Definition]
ChEBI: An O-acyl-L-carnitine where the acyl group specified is acetyl. It facilitates movement of acetyl-CoA into the matrices of mammalian mitochondria during the oxidation of fatty acids. | [IC 50]
Human Endogenous Metabolite |
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