| Identification | Back Directory | [Name]
5-bromo-5'-phenyl-1,2',3,3'-tetrahydrospiro[2H-indole-3,2'-(1,3,4)-thiadiazole]-2-one | [CAS]
297180-15-5 | [Synonyms]
CB16.2 aka
5-bromo-5'-phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one
5-bromo-5'-phenyl-3'H-spiro[indole-3,2'-[1,3,4]thiadiazol]-2(1H)-one
Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-bromo-5'-phenyl-
5-bromo-5'-phenyl-1,2',3,3'-tetrahydrospiro[2H-indole-3,2'-(1,3,4)-thiadiazole]-2-one | [Molecular Formula]
C15H10BrN3OS | [MOL File]
297180-15-5.mol | [Molecular Weight]
360.23 |
| Chemical Properties | Back Directory | [density ]
1.76±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
Soluble in DMSO (up to 20 mg/ml). | [form ]
solid | [pka]
0.44±0.20(Predicted) | [color ]
Off-white | [Stability:]
Stable for 1 year from date of purchase? as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| Hazard Information | Back Directory | [Description]
Lipofermata (297180-15-5) is an inhibitor of fatty acid transport protein 2 (FATP2; IC50?= 4.84 μM).1?It does not inhibit glucose transport or the activity of long chain acyl-CoA synthetase. It prevented palmitate-mediated oxidative stress, induction of BiP and CHOP, and cell death in a dose-dependent manner in hsHepG2 and mINS-1E cells suggesting utility in preventing fatty acid-mediated cell death pathways and lipotoxic disease.2?Inhibition was specific for long and very long chain fatty acids but not medium (C6-C10) acids. Lipofermata abrogates lipid transport into melanoma cells and reduces melanoma growth and invasion.3 | [Uses]
Lipofermata is a fatty acid transport proteins (FATPs) inhibitor. | [storage]
Store at -20°C | [References]
1) Sandoval?et al.?(2010),?Identification and characterization of small compound inhibitors of human FATP2; Biochem. Pharmacol.?79?990
2) Ahowesso?et al.?(2015),?Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death; Biochem. Pharmacol.?98?167
3) Zhang?et al.?(2018),?Adipocyte-derived lipids mediate melanoma progression via FATP proteins; Cancer Discov.?8?1006
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DC Chemicals
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021-58447131 13564518121 |
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