| Identification | Back Directory | [Name]
4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid | [CAS]
29553-70-6 | [Synonyms]
4-CPPC
(4CPPC)
4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid
2,5-Pyridinedicarboxylic acid, 4-(3-carboxyphenyl)- | [Molecular Formula]
C14H9NO6 | [MOL File]
29553-70-6.mol | [Molecular Weight]
287.22 |
| Hazard Information | Back Directory | [Biological Activity]
4-CPPC is an inhibitor of macrophage migration inhibitory factor-2 (MIF-2; IC50 = 27 μM).1 It is selective for MIF-2 over MIF-1 (IC50 = 450 μM). It inhibits MIF-2, but not MIF-1, binding to CD74 in vitro when used at a concentration of 10 μM. 4-CPPC (5, 10, and 25 μM) inhibits MIF-2-induced ERK1/2 phosphorylation in primary human skin fibroblasts. | [References]
1.Tilstam, P.V., Pantouris, G., Corman, M., et al.A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activityJ. Biol. Chem.294(49)18522-18531(2019)
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