| Identification | Back Directory | [Name]
2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione | [CAS]
2924858-25-1 | [Synonyms]
2-(2,6-dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione | [Molecular Formula]
C17H17N3O5 | [MOL File]
2924858-25-1.mol | [Molecular Weight]
343.33 |
| Chemical Properties | Back Directory | [Boiling point ]
643.7±55.0 °C(predicted) | [density ]
1.460±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
10.83±0.40(predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
PT-179 is an orthogonal Thalidomide (HY-14658) derivative that targets cereblon without causing off-target degradation effects. PT-179 is able to specifically bind CRBN, form a ternary complex with a target protein fused to a zinc finger (ZF) degron, and mediate the degradation of the tagged protein. For example, PT-179 binds to the ubiquitin ligase substrate receptor cereblon by forming a complex with SD40 and efficiently degrades proteins N- or C-terminally fused to SD40 or SD36 (DC50 for eGFP: 4.5 nM and 14.3 nM). PT-179 can be used to develop compact protein degradation tagging platforms[1]. | [IC 50]
Cereblon | [References]
[1] Mercer JAM, et al. Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science. 2024 Mar 15;383(6688):eadk4422. DOI:10.1126/science.adk4422 |
|
|