| Identification | Back Directory | [Name]
CANTHARIDIC ACID | [CAS]
28874-45-5 | [Synonyms]
CANTHARIDIC ACID
CANTHARIDIC ACID DISODIUM SALT
Cantharidic Acid - CAS 28874-45-5 - Calbiochem
5'-3'2,3-DICARBOXY-2,3-DIMETHYL-1,4-EPOXYCYCLOHEXANE
EXO-1,6-DICARBOXY-ENDO-1,6-DIMETHYL-7-OXABICYCLO[2,2,1]HEPTANE
EXO-1,6-DICARBOXY-ENDO-1,6-DIMETHYL-7-OXABICYLCO[2,2,1]HEPTANE | [Molecular Formula]
C8H10O5 | [MDL Number]
MFCD00047137 | [MOL File]
28874-45-5.mol | [Molecular Weight]
186.16 |
| Chemical Properties | Back Directory | [Melting point ]
216-218℃ | [Boiling point ]
407.8±40.0 °C(Predicted) | [density ]
1.359±0.06 g/cm3(Predicted) | [storage temp. ]
+15C to +30C | [solubility ]
Soluble in DMSO (100 mM) and in ethanol (25 mM, gentle warming) | [form ]
White solid | [pka]
3.70±0.40(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
Potent and selective inhibitor of PP2A, IC50=53nM (IC50 for PP1=562nM). Useful for inhibiting PP1 and PP2A during purification of phosphorylated proteins. | [Definition]
ChEBI: A monoterpenoid with an epoxy-bridged bicyclic dicarboxylic acid structure, which acts as an inhibitor of protein phosphatases 1 and 2A. | [Biological Activity]
Cell permeable: no''Primary Target
PP2A''Product does not compete with ATP.''Reversible: no''Target IC50: 50 nM against protein phosphatase 2A | [storage]
Room temperature | [References]
[1] Chen YC, et al., Cantharidic acid induces apoptosis in human nasopharyngeal carcinoma cells through p38-mediated upregulation of caspase activation. Environ Toxicol. 2020 May;35(5):619-627. DOI:10.1002/tox.22897 |
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Merck KGaA
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Abcam Limited
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