| Identification | Back Directory | [Name]
O-(2-AMINOETHYL)-5Z,8Z,11Z,14Z-EICOSATETRAENOATE | [CAS]
287937-12-6 | [Synonyms]
VIRODHAMINE
AURORA KA-7837
O-(2-AMINOETHYL)-5Z,8Z,11Z,14Z-EICOSATETRAENOATE
5,8,11,14-Eicosatetraenoic acid, 2-aminoethyl ester, (5Z,8Z,11Z,14Z)- | [Molecular Formula]
C22H37NO2 | [MDL Number]
MFCD06654562 | [MOL File]
287937-12-6.mol | [Molecular Weight]
347.53 |
| Chemical Properties | Back Directory | [Boiling point ]
450.3±45.0 °C(Predicted) | [density ]
0.930±0.06 g/cm3(Predicted) | [storage temp. ]
Desiccate at -20°C | [form ]
Viscous Liquid | [pka]
7.68±0.10(Predicted) | [color ]
Yellow to brown |
| Hazard Information | Back Directory | [Uses]
Virodhamine is an endogenous cannabinoid receptor mixed antagonist/agonist. | [Definition]
ChEBI: O-Arachidonoyl ethanolamine is a fatty acid ester. | [Biological Activity]
Endogenous cannabinoid receptor mixed agonist/antagonist found in higher concentrations peripherally than anandamide. Full agonist at GPR55 and CB 2 and partial agonist/antagonist at CB 1 (EC 50 values are 12, 381 and 2920 nM at GPR55, CB 2 and CB 1 receptors respectively). Induces hypothermia in vivo . Also available as part of the Cannabinoid Receptor Agonist Tocriset™ and Endocannabinoid Tocriset™ . | [in vivo]
Virodhamine (1-10 mg/kg; i.p. once) repairs the nicotine (0.8 mg/kg) and immobilization stress induced anxiety in vivo[2]. | Animal Model: | Male ICR mice with nicotine (0.8 mg/kg) and immobilization stress induced anxiety[2] | | Dosage: | 1, 5 and 10 mg/kg | | Administration: | Intraperitoneal injection; 1-10 mg/kg; once | | Result: | Significantly repaired the working memory impairment-like behaviors s at a does of 5 mg/kg and showed significant anxiolytic-like effects against the anxiety-like behaviors at a does of 10 mg/kg.
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Energy Chemical
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