| Identification | Back Directory | [Name]
Benzoic acid, 3-[[[1,2-dihydro-2-oxo-4-phenoxy-6-(trifluoromethyl)-3-pyridinyl]carbonyl]amino]- | [CAS]
2763260-34-8 | [Synonyms]
Benzoic acid, 3-[[[1,2-dihydro-2-oxo-4-phenoxy-6-(trifluoromethyl)-3-pyridinyl]carbonyl]amino]- | [Molecular Formula]
C20H13F3N2O5 | [MOL File]
2763260-34-8.mol | [Molecular Weight]
418.32 |
| Chemical Properties | Back Directory | [Boiling point ]
581.6±50.0 °C(Predicted) | [density ]
1.531±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
4.05±0.10(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 μM and a Kd of 54.8 nM[1].
NRX-2663 displays both improved potency in the binding assay with pSer33/Ser37 β-catenin (EC50 of 80 μM) and cooperativity of binding (13-fold). NRX-2663 also markedly enhances the ubiquitylation of the pSer33/Ser37 β-catenin peptide, with ubiquitin chain formation at ligand concentrations of 16 μM and above resembling ubiquitin chain formation on wild-type pSer33/pSer37 β-catenin peptide[1]. | [References]
[1]. Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402. |
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