| Identification | Back Directory | [Name]
3,3'-Bipyridine, 6-[2-(4-fluorophenyl)ethoxy]- | [CAS]
2761063-79-8 | [Synonyms]
ELOVL1-IN-2
3,3'-Bipyridine, 6-[2-(4-fluorophenyl)ethoxy]- | [Molecular Formula]
C18H15FN2O | [MOL File]
2761063-79-8.mol | [Molecular Weight]
294.32 |
| Chemical Properties | Back Directory | [Boiling point ]
461.5±45.0 °C(Predicted) | [density ]
1.193±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 6.67 mg/mL (22.66 mM; ultrasonic and adjust pH to 3 with HCl) | [form ]
Solid | [pka]
3.42±0.12(Predicted) | [color ]
Off-white to light brown |
| Hazard Information | Back Directory | [Uses]
ELOVL1-IN-2 is an elongation of very long chain fatty acid 1 (ELOVL1) enzyme inhibitor, ELOVL1-IN-2 shows weak ELOVL1 inhibition (IC50=21 μM) and moderate potency in a primary cellular assay (HEK293 C26 IC50=6.7 μM) [1]. | [References]
[1] Boyd MJ, Collier PN, Clark MP, et al. Discovery of Novel, Orally Bioavailable Pyrimidine Ether-Based Inhibitors of ELOVL1. J Med Chem. 2021;64(24):17777-17794. DOI:10.1021/acs.jmedchem.1c00948 |
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DC Chemicals
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