| Identification | Back Directory | [Name]
2-Propenamide, N-[1-[8-[[3-methyl-4-[(1-methyl-1H-benzimidazol-5-yl)oxy]phenyl]amino]pyrimido[5,4-d]pyrimidin-2-yl]-4-piperidinyl]- | [CAS]
2728667-27-2 | [Synonyms]
BI-1810631
Zongertinib
N-[1-[4-[3-methyl-4-(1-methylbenzimidazol-5-yl)oxy-anilino]pyrimido[5,4-d]pyrimidin-6-yl]-4-piperidyl]prop-2-enamide
N-(1-(8-((3-methyl-4-((1-methyl-1H-benzo[d]imidazol-5-yl)oxy)phenyl)amino)pyrimido[5,4-d]pyrimidin-2-yl)piperidin-4-yl)acrylamide
2-Propenamide, N-[1-[8-[[3-methyl-4-[(1-methyl-1H-benzimidazol-5-yl)oxy]phenyl]amino]pyrimido[5,4-d]pyrimidin-2-yl]-4-piperidinyl]- | [Molecular Formula]
C29H29N9O2 | [MOL File]
2728667-27-2.mol | [Molecular Weight]
535.6 |
| Hazard Information | Back Directory | [Uses]
Zongertinib (BI 1810631) is a potent and selective HER2 and EGFR tyrosine kinase inhibitor with IC50 values of 13 nM and 579 nM, respectively. Zongertinib has antitumor activity and can be used in the study of multiple solid tumors[1][2][3]. | [References]
[1] WHO Drug Informat ion - World Health Organization (WHO).
[2] Wilding Birgit, et al. Synthesis of diazino-pyrimidines as anticancer agents: World Intellectual Property Organization, WO2021213800. 2021-10-28.
[3] Li S, et al. Emerging Targeted Therapies in Advanced Non-Small-Cell Lung Cancer. Cancers (Basel). 2023 May 24;15(11):2899. DOI:10.3390/cancers15112899 |
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CAREBIO PHARMA Gold
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18501057619 18501057619 |
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