| Identification | Back Directory | [Name]
Naphth[2,3,-b]oxiren-2(1aH)-one, 4, | [CAS]
27062-01-7 | [Synonyms]
Isonardosinone
Naphth[2,3,-b]oxiren-2(1aH)-one, 4,
(1aS)-4,5,6,6a,7,7aβ-Hexahydro-7α-(1-hydroxy-1-methylethyl)-6β,6aβ-dimethylnaphth[2,3-b]oxiren-2(1aβH)-one
Naphth[2,3-b]oxiren-2(1aH)-one, 4,5,6,6a,7,7a-hexahydro-7-(1-hydroxy-1-methylethyl)-6,6a-dimethyl-, (1aS,6R,6aR,7S,7aS)- | [Molecular Formula]
C15H22O3 | [MOL File]
27062-01-7.mol | [Molecular Weight]
250.33 |
| Hazard Information | Back Directory | [Uses]
Isonardosinone is a nardosinone-type sesquiterpenes, which can be isolated from Valerianaceae. Isonardosinone inhibits NF-κB and MAPK signaling pathway, suppresses expression of iNOS and cyclooxygenase-2 (COX-2) in Lipopolysaccharides (HY-D1056)-induced BV2 microglia, exhibits anti-inflammatory activity[1]. | [References]
[1] Ko W, et al., Nardosinone-Type Sesquiterpenes from the Hexane Fraction of Nardostachys jatamansi Attenuate NF-κB and MAPK Signaling Pathways in Lipopolysaccharide-Stimulated BV2 Microglial Cells. Inflammation. 2018 Aug;41(4):1215-1228. DOI:10.1007/s10753-018-0768-9 |
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