| Identification | Back Directory | [Name]
6-Quinolinecarboxamide, 2-amino-3-methyl-N-[(1R)-1-(2-pyrimidinyl)ethyl]-N-[[5-(trifluoromethyl)-2-pyridinyl]methyl]- | [CAS]
2691869-82-4 | [Synonyms]
AM-9747
2-amino-3-methyl-N-[(1R)-1-pyrimidin-2-ylethyl]-N-[[5-(trifluoromethyl)-2-pyridyl]methyl]quinoline-6-carboxamide
6-Quinolinecarboxamide, 2-amino-3-methyl-N-[(1R)-1-(2-pyrimidinyl)ethyl]-N-[[5-(trifluoromethyl)-2-pyridinyl]methyl]- | [Molecular Formula]
C24H21F3N6O | [MOL File]
2691869-82-4.mol | [Molecular Weight]
466.46 |
| Chemical Properties | Back Directory | [Boiling point ]
635.7±55.0 °C(Predicted) | [density ]
1.362±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
5.98±0.50(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
PRMT5-IN-25 (compound 503) is a potent PRMT5 inhibitor with an Ki value of 0.06 nM. PRMT5-IN-25 shows antiproliferative[1]. | [IC 50]
PRMT5: 0.06 nM (Ki) | [References]
[1] Jennifer Rebecca Allen, et al. Novel prmt5 inhibitors. WO2021163344A1. |
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