| Identification | Back Directory | [Name]
1,3,4-Oxadiazole-2-carboxamide, N-[(3,4-dichlorophenyl)methyl]-5-(2-thienyl)- | [CAS]
2685795-52-0 | [Synonyms]
SDH-IN-1
1,3,4-Oxadiazole-2-carboxamide, N-[(3,4-dichlorophenyl)methyl]-5-(2-thienyl)- | [Molecular Formula]
C14H9Cl2N3O2S | [MOL File]
2685795-52-0.mol | [Molecular Weight]
354.21 |
| Chemical Properties | Back Directory | [density ]
1.485±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 16.67 mg/mL (47.06 mM; ultrasonic and warming and heat to 80°C) | [form ]
Solid | [pka]
11.55±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SDH-IN-1 (compound 4i) is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 4.53 μM. SDH-IN-1 has potent antifungal activities. SDH-IN-1 displays potent activity against S. sclerotiorum (EC50 of 0.14 mg/L)[1]. | [storage]
4°C, protect from light | [References]
[1] Zihui Yang, et al. Design, Synthesis, and Antifungal Activity of Novel Thiophene/Furan-1,3,4-Oxadiazole Carboxamides as Potent Succinate Dehydrogenase Inhibitors. J Agric Food Chem. 2021 Nov 17;69(45):13373-13385. DOI:10.1021/acs.jafc.1c03857 |
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