| Identification | Back Directory | [Name]
HARRINGTONINE | [CAS]
26833-85-2 | [Synonyms]
HT
nsc124147
(3(r))-ter
HARRINGTONIN
HARRINGTONINE
2'R-HARRINGTONINE
HARRINGTONINE98%,99%
Harringtonine 26833-85-2
alkaloidcfromcephalotaxus
HARRINGTONINE(P) USP/EP/BP
2’R-Harringtonine,Harringtonin
3-methylbutyl)butanedioate (ester), [3(R)]-
Cephalotaxine, 4-methyl 2-hydroxy-2-(3-hydroxy-
Harringtonine, 98%, from Taxus chinensis (Pilg.) Rehder
4-methyl-cephalotaxin2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate(es
cephalotaxine,4-methyl(2r)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioat
3-[4-Methyl (2R)-2-hydroxy-2-(3-hydroxy-3-Methylbutyl)butanedioate]cephalotaxine
Cephalotaxine, 3-[4-methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate]
Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate (ester)
2-Hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioic acid 1-[(3R)-3-deoxycephalotaxin-3-yl]4-methyl ester | [Molecular Formula]
C28H37NO9 | [MDL Number]
MFCD00056888 | [MOL File]
26833-85-2.mol | [Molecular Weight]
531.59 |
| Chemical Properties | Back Directory | [Melting point ]
73～75℃ | [Boiling point ]
679.4±55.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml | [form ]
A crystalline solid | [pka]
11.62±0.29(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Description]
Harringtonine is a natural alkaloid that inhibits protein synthesis at low micromolar concentrations.1 It immobilizes ribosomes immediately after the initiation of translation.1,2 While harringtonine has drawn some interest in mitigating cancer, its homolog homoharrington is more effective, particularly for chronic myelogenous leukemia.3,4,5 The ability of harringtonine to immobilize initiating ribosomes can be used to capture ribosome-protected mRNA fragments for evaluating translation.2 | [Description]
The full structure of harringtonine has now been established from a study of the
hydrolysis products of this base. | [Chemical Properties]
White Solid | [Uses]
A natural product with significant antitumor activities. | [Uses]
specific anti-leukemia drug | [Definition]
ChEBI: Harringtonine is an alkaloid. | [References]
Mikolajczak, Powell, Smith, Tetrahedron, 28, 1995 (1972)
Kelly, McKenna, Christenson, Tetrahedron Lett., 35m (1973) |
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