Identification | Back Directory | [Name]
CDK5-IN-2 | [CAS]
2639542-22-4 | [Synonyms]
CDK5-IN-2 [1,1'-Biphenyl]-3-carbonitrile, 3'-fluoro-4'-[[2-[(1R)-1-hydroxy-1-(1-methyl-4-piperidinyl)ethyl]-1,6-naphthyridin-7-yl]amino]- | [Molecular Formula]
C29H28FN5O | [MOL File]
2639542-22-4.mol | [Molecular Weight]
481.58 |
Hazard Information | Back Directory | [Uses]
CDK5-IN-2 (compound 15) is a highly selective CDK5 inhibitor with IC50s of 0.2 and 23 for CDK5/p25 and CDK2/CycA, respectively[1]. | [IC 50]
Cdk5/p25: 0.2 nM (IC50); CDK2/CycA: 23 nM (IC50) | [References]
[1] Daniels MH, et al. Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022;65(4):3575-3596. DOI:10.1021/acs.jmedchem.1c02069 |
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