| Identification | Back Directory | [Name]
MRTX-1719 | [CAS]
2630904-45-7 | [Synonyms]
Benzonitrile, 2-[4-[4-(aminomethyl)-1,2-dihydro-1-oxo-6-phthalazinyl]-1-methyl-1H-pyrazol-5-yl]-4-chloro-6-(cyclopropyloxy)-3-fluoro-, (2R)- | [Molecular Formula]
C23H18ClFN6O2 | [MOL File]
2630904-45-7.mol | [Molecular Weight]
464.89 |
| Chemical Properties | Back Directory | [density ]
1.58±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
11.37±0.40(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
MRTX-1719 is a potent first-in-class selective inhibitor of the PRMT5/MTA complex, with an IC50 of less than 10 nM in PRMT5/MTA MTAPDEL SDMA cells[1]. | [storage]
Store at -20°C | [References]
[1]. Targeting the genetic and immunological drivers of cancer. |
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