| Identification | Back Directory | [Name]
POLY-L-HISTIDINE HYDROCHLORIDE MW | [CAS]
26062-48-6 | [Synonyms]
polyhistidine
poly-L-histidine chloride
poly-L-HistidineMW5000-15000
POLY-L-HISTIDINE HYDROCHLORIDE MW
POLY-L-HISTIDINE MOL WT 5000-15000
Poly-L-histidine mol wt 5,000-25,000
POLY-L-HISTIDINE, HYDROCHLORIDE*MW 15,00 0-50,000 | [Molecular Formula]
C6H9N3O2 | [MDL Number]
MFCD00166382 | [MOL File]
26062-48-6.mol | [Molecular Weight]
155.16 |
| Hazard Information | Back Directory | [Uses]
Poly-L-histidine has been used:
- as a polycation for the dispersion of multi-wall carbon nanotubes (MWCNTs)
- as a polyionic compound to investigate its ability to rupture extracellular enveloped virus membrane
- in screening its anti-prion activity in cell based and in vivo anti-prion assay
| [Definition]
ChEBI: Histidine is an alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3. It has a role as a metabolite. It is an alpha-amino acid, a member of imidazoles, an aromatic amino acid and a polar amino acid. It contains a 1H-imidazol-4-ylmethyl group. It is a conjugate base of a histidinium(1+). It is a conjugate acid of a histidinate(1-). | [General Description]
Poly-L-histidine is an amphoteric compound. The imidazole ring in its structure enables protonation?deprotonation. | [Biochem/physiol Actions]
Poly-L-histidine (Phis) copolymers are biocompatible, pH responsive and are less toxic. It exhibits endolysosomal escape funcationality. The copolymer of Phis with poly(ethylene glycol)?poly(d,l-lactide) (PEG-PLA) is effective in delivering doxorubicin. pH sensitive poly(l-histidine) copolymer micelles have application in delivering anticancer drugs in acidic microenvironment. |
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