| Identification | Back Directory | [Name]
AC2-12 | [CAS]
256447-08-2 | [Synonyms]
ANX1
LPC1
ANXA-1
AC2-12
ANNEXIN 1
Annexin A1
AC-AMVSEFLKQAW
Annexin A1 (1-11)
Annexin 1 (ANXA - 1
Annexin A1 (1-11) (dephosphorylated)
AC-ALA-MET-VAL-SER-GLU-PHE-LEU-LYS-GLN-ALA-TRP-OH
Recombinant Human Annexin A1/ANXA1 Protein, No Tag
ANTI-ANNEXIN A1 (CENTER) antibody produced in rabbit
L-Tryptophan, N-acetyl-L-alanyl-L-methionyl-L-valyl-L-seryl-L-α-glutamyl-L-phenylalanyl-L-leucyl-L-lysyl-L-glutaminyl-L-alanyl-
Annexin-1 (2-12) (huMan, bovine, chicken, porcine), Lipocortin-1 (2-12), Calpactin II (1-11) (dephosphorylated) (huMan, bovine, chicken, porcine)
Annexin A1 (1-11) (dephosphorylated) (human, bovine, chicken, porcine) trifluoroacetate salt Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-OH trifluoroacetate salt
Annexin A1 (1-11) (dephosphorylated) (huMan, bovine, chicken, porcine)
Annexin-1 (2-12) (huMan, bovine, chicken, porcine), Lipocortin-1 (2-12), Calpactin II (1-11) (dephosphorylated) (huMan, bovine, chicken, porcine) | [Molecular Formula]
C63H94N14O17S | [MDL Number]
MFCD06411599 | [MOL File]
256447-08-2.mol | [Molecular Weight]
1351.57 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
Soluble to 1 mg/ml in 20% acetonitrile / Water | [Sequence]
Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-OH |
| Hazard Information | Back Directory | [Enzyme inhibitor]
This annexin/lipocortin-1 peptidomimetic (FW = 1351.58 g/mol; Sequence: Acetyl-AMVSEFLKQAW; CAS 256447-08-2; Soluble to 1 mg/mL in 20% (vol/vol) acetonitrile-H2O) markedly reduces the degree of neutrophil adhesion and emigration across mouse mesenteric postcapillary venules, when administered at 13 mg/kg (s.c.), but does not modify cell rolling, when assessed directly by intravital microscopy. Ac2-12 also promotes neutrophil detachment from mesenteric endothelium after activation by intraperitoneal injection of 1 mg zymosan in mice (i.e., zymosan peritonitis). Ac2-12 phenocopies the effects observed in FormylatedPeptide Receptor (FPR) knock-out mice. |
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