| Identification | Back Directory | [Name]
Adenylyl Imidodiphosphate | [CAS]
25612-73-1 | [Synonyms]
AMP-PNP
AMP-P(NH)P
β,γ-ImidoATP
β,γ-Imido-ATP
Adenyl imidodiphosphate
Adenylyl Imidodiphosphate
Adenylyl beta,gamma-imidodiphosphate
Adenosine 5′-(β,γ-imido)triphosphate
Adenosine beta,gamma-imidotriphosphate
Adenosine 5'-[β,γ-imide]triphosphoric acid
Adenosine 5'-(beta,gamma-imidotriphosphate)
Adenosine 5'-(beta,gamma-iminotriphosphate)
Adenylyl imidodiphosphate lithium salt hydrate
β,γ-Imidoadenosine 5′-triphosphate lithium salt hydrate
Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate
5'-Adenylic acid, anhydride with imidodiphosphoric acid (1:1)
5'-Adenylic acid, monoanhydride with imidodiphosphoric acid (8ci,9ci)
Adenosine, 5'-o-[hydroxy[[hydroxy(phosphonoamino)phosphinyl]oxy]phosphinyl]- | [EINECS(EC#)]
277-127-5 | [Molecular Formula]
C10H17N6O12P3 | [MOL File]
25612-73-1.mol | [Molecular Weight]
506.2 |
| Chemical Properties | Back Directory | [Boiling point ]
965.5±75.0 °C(Predicted) | [density ]
2.65±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
H2O: soluble50mg/mL | [form ]
powder | [pka]
1.16±0.50(Predicted) | [color ]
white | [biological source]
natural (organic) | [Water Solubility ]
H2O: 50mg/mL | [BRN ]
6047109 |
| Hazard Information | Back Directory | [Uses]
Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate has been used in a study to research the effects of monovalent cations Li+, Na+, K+, NH4+, Rb+ and Cs+ on the solid and solution structures of the nucleic acid components. Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate has also been used in a study to determine that antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide. | [Uses]
AMP-PNP is a competitive inhibitor of most ATP-dependent systems. A good substrate for enzymes hydrolyzing between the α- and β-phosphorus atom, yet is resistant to enzymes cleaving between the β- and γ-phosphorus atom. Substrate of snake venom phosphodiesterase and adenylate cyclase.
AMP-PNP has been used for two-motor fluorescence assay. | [Definition]
ChEBI: AMP-PNP is an adenosine 5'-phosphate. | [General Description]
AMP-PNP(adenylyl-imidodiphosphate) is an artificial substrate of enzyme, adenylate cyclase. Adenylate cyclase helps to hydrolyze adenylyl-imidodiphosphate slowly than ATP. | [Biochem/physiol Actions]
A non-hydrolyzable ATP analog. AMP-PNP competitively inhibits ATP-dependent enzyme systems, such as glutamine synthetase. It inhibits a number of enzymes which require the hydrolysis of ATP such as DNA topoisomerase II, SV40 large T-antigen helicase and a number of kinases. Blocks ATP-sensitive calcium-dependent potassium channels. |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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