| Identification | Back Directory | [Name]
5-Pyrimidinecarboxamide, 2-[(4,6-dimethyl-2-pyridinyl)amino]-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-, hydrochloride (1:1) | [CAS]
2550393-38-7 | [Synonyms]
5-Pyrimidinecarboxamide, 2-[(4,6-dimethyl-2-pyridinyl)amino]-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-, hydrochloride (1:1) | [Molecular Formula]
C23H25ClN6O | [MOL File]
2550393-38-7.mol | [Molecular Weight]
436.94 |
| Hazard Information | Back Directory | [Description]
TG11-77 is a brain-permeable antagonist of the prostaglandin E2 (PGE2) receptor subtype EP2 (KB = 9.7 nM).1 It is selective for EP2 over DP1, EP4, and IP receptors (KBs = 7,320, 5,300, and >10,000 nM, respectively). TG11-77 (0.3 and 1 μM) inhibits the expression of genes encoding COX-2, IL-1β, and IL-6 induced by LPS and the EP2 receptor agonist ONO-AE1-259-01 in mouse BV-2 microglia expressing human EP2 receptors. | [References]
1. Amaradhi, R., Banik, A., Mohammed, S., et al. Potent, selective, water soluble, brain-permeable EP2 receptor antagonist for use in central nervous system disease models J. Med. Chem. 63(3),1032-1050(2020). |
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