| Identification | Back Directory | [Name]
8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester | [CAS]
25368-09-6 | [Synonyms]
β-Crocetin
crocetin monomethyl ester
8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester
2,4,6,8,10,12,14-Hexadecaheptaenedioic acid, 2,6,11,15-tetramethyl-, monomethyl ester, (2E,4E,6E,8E,10E,12E,14E)- (9CI) | [Molecular Formula]
C21H26O4 | [MDL Number]
MFCD32200978 | [MOL File]
25368-09-6.mol | [Molecular Weight]
342.43 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C, sealed storage, away from moisture and light | [solubility ]
Soluble in DMSO | [form ]
Solid | [color ]
Pink to red |
| Hazard Information | Back Directory | [Uses]
Crocetin monomethyl ester, isolated from Crocus sativus, possesses anti-inflammatory, neuroprotective and antioxidant activity[1][2]. Crocetin monomethyl ester promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway[4]. | [References]
[1] Tseng TH, et al. Crocetin protects against oxidative damage in rat primary hepatocytes. Cancer Lett. 1995 Oct 20;97(1):61-7. DOI:10.1016/0304-3835(95)03964-x
[2] Ahmad AS, et al. Neuroprotection by crocetin in a hemi-parkinsonian rat model. Pharmacol Biochem Behav. 2005 Aug;81(4):805-13. DOI:10.1016/j.pbb.2005.06.007
[3] Nam KN, et al. Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells. Eur J Pharmacol. 2010 Dec 1;648(1-3):110-6. DOI:10.1016/j.ejphar.2010.09.003
[4] Wani A, Al Rihani SB, Sharma A, et al. Crocetin promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway. Autophagy. 2021;17(11):3813-3832. DOI:10.1080/15548627.2021.1872187 |
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