| Identification | Back Directory | [Name]
AVE8062A | [CAS]
253426-24-3 | [Synonyms]
AC 7700
AVE8062A
Ombrabulin HCl
AC7700 (hydrochloride)
AVE8062 (hydrochloride)
Ombrabulin (AVE8062) HCl
Ombrabulin (hydrochloride)
Ombrabulin (AVE8062) hydrochloride
Ombrabulin hydrochloride >=98% (HPLC) | [EINECS(EC#)]
682-340-5 | [Molecular Formula]
C21H27ClN2O6 | [MOL File]
253426-24-3.mol | [Molecular Weight]
438.902 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble; Ethanol: soluble | [form ]
powder | [color ]
white to beige | [Water Solubility ]
H2O: 20mg/mL, clear |
| Hazard Information | Back Directory | [General Description]
Ombrabulin is a member of the combretastatin A-4 compound class and is a tubulin-depolymerising tumour vascular-disrupting compound. | [Biochem/physiol Actions]
Ombrabulin is a synthetic water-soluble combretastatin analog vascular disrupting agent. Ombrabulin is a tubulin polymerization inhibitor. Ombrabulin binds to the colchicine binding site of endothelial cell tubulin, inhibiting tubulin polymerization and inducing mitotic arrest and apoptosis in endothelial cells. |
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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Musechem
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www.musechem.com |
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DC Chemicals
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Energy Chemical
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http://www.energy-chemical.com |
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