| Identification | Back Directory | [Name]
TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA | [CAS]
252881-74-6 | [Synonyms]
H2N-PEG3-tBu
NH2-PEG3-C2-Boc
Amino-PEG3-COOtBu
H2N-PEG3-CH2CH2COOtBu
NH2-PEG3-CH2CH2COOtBu
Amino-PEG3-tert-butyl ester
[(+)-BIOTIN-PEG12-NHS ESTER]
H2N-PEG3-CH2CH2-t-butylester
tert-Butyl 12-aMino-4,7,10-trioxa-dodec
TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA
tert-Butyl 3-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)propanoate
tert-butyl 3-(2-(2-(2-aminoethoxyl)ethoxy)ethoxy)propanoate
tert-butyl 3-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}propanoate
tert-Butyl 12-amino-4,7,10-trioxadodecanoate technical, >=80% (T)
3-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]propionic acid tert-butyl ester
Propanoic acid,3-[2-[2-(2-aMinoethoxy)ethoxy]ethoxy]-, 1,1-diMethylethyl ester | [Molecular Formula]
C13H27NO5 | [MDL Number]
MFCD06201017 | [MOL File]
252881-74-6.mol | [Molecular Weight]
277.358 |
| Chemical Properties | Back Directory | [Boiling point ]
358.5±27.0 °C(Predicted) | [density ]
1.029±0.06 g/cm3(Predicted) | [Fp ]
169.7 °C | [storage temp. ]
−20°C
| [pka]
8.74±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Amino-PEG3-t-butyl ester is a PEG linker containing an amino group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
tert-Butyl 12-amino-4,7,10-trioxadodecanoate is generally used as a spacer or linker in bioconjugate chemistry. Some of its applications are:
- Synthesis of the tetanus-toxin conjugate of MUC1 glycopeptide antigen, as a potential antitumor vaccine.
- Synthesis of self-assembled monolayer-based surface-enhanced raman scattering (SERS) labels for immuno-SERS microscopy.
- Synthesis of polycationic adamantane-based dendrons for cell imaging.
- Synthesis of phthalocyanine (Pc)-peptide conjugates as potential fluorescence imaging agents for cancers overexpressing epidermal growth factor receptors (EGFR).
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