| Identification | Back Directory | [Name]
Mal-PEG4-amine TFA salt | [CAS]
2512227-13-1 | [Synonyms]
Mal-PEG5-amine
Mal-PEG4-C2-NH2 TFA
1-(14-amino-3,6,9,12-tetraoxatetradecyl)pyrrolidine-2,5-dione 2,2,2-trifluoroacetate | [Molecular Formula]
C16H25F3N2O8 | [MDL Number]
MFCD31920055 | [MOL File]
2512227-13-1.mol | [Molecular Weight]
430.38 |
| Hazard Information | Back Directory | [Biological Activity]
Mal-PEG4-C2-NH2 TFA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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