| Identification | Back Directory | [Name]
GMB-475 | [CAS]
2490599-18-1 | [Synonyms]
GMB-475
(2S,4R)-1-((S)-3,3-Dimethyl-2-(2-(2-(4-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)phenoxy)ethoxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide | [Molecular Formula]
C43H46F3N7O7S | [MOL File]
2490599-18-1.mol | [Molecular Weight]
861.94 |
| Chemical Properties | Back Directory | [Boiling point ]
1029.7±65.0 °C(Predicted) | [density ]
1.337±0.06 g/cm3(Predicted) | [solubility ]
DMSO:145.4(Max Conc. mg/mL);168.69(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);58.01(Max Conc. mM) | [form ]
Solid | [pka]
13.50±0.46(Predicted) | [color ]
Light yellow to yellow | [InChIKey]
ONDVWISBMHHLGZ-XAYQSWBHNA-N | [SMILES]
C(N1C[C@H](O)C[C@H]1C(=O)NCC1C=CC(C2=C(N=CS2)C)=CC=1)(=O)[C@H](C(C)(C)C)NC(=O)COCCOC1C=CC(C2=NC=NC(NC3C=CC(OC(F)(F)F)=CC=3)=C2)=CC=1 |&1:3,6,24,r| |
| Hazard Information | Back Directory | [Description]
GMB-475 acts as a degrader of BCR-ABL 1 tyrosine kinase and as a recruiter of the E3 ligase Von Hippel Lindau (VHL) resulting in ubiquitination and subsequent degradation of oncogenic fusion proteins. | [storage]
Store at -20°C |
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| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Website: |
http://m.is0513.com/ShowSupplierProductsList927327/0.htm |
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