| Identification | Back Directory | [Name]
1,6-Naphthyridine-6(5H)-carboxamide, N-[2-(4-fluorophenoxy)-5-pyrimidinyl]-5-(4-fluorophenyl)-7,8-dihydro-, (5S)- | [CAS]
2471967-92-5 | [Synonyms]
BAY-899
1,6-Naphthyridine-6(5H)-carboxamide, N-[2-(4-fluorophenoxy)-5-pyrimidinyl]-5-(4-fluorophenyl)-7,8-dihydro-, (5S)- | [Molecular Formula]
C25H19F2N5O2 | [MDL Number]
MFCD32263051 | [MOL File]
2471967-92-5.mol | [Molecular Weight]
459.45 |
| Chemical Properties | Back Directory | [density ]
1.397±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 1mg/mL, clear | [form ]
Solid | [pka]
12.52±0.40(Predicted) | [color ]
White to off-white | [optical activity]
[α]/D 165 to 195°, c =1 in chloroform-d |
| Hazard Information | Back Directory | [Biological Activity]
BAY-899 is an orally availablepotent and selective antagonist of the human luteinizing hormone receptor (hLH-R) th at reduces sex hormone levels in several animal models. BAY-899 likely binds to a putative rhodopsin-like binding cavity located within the 7-transmembrane region of the hLH-receptor. |
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DC Chemicals
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Merck KGaA
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www.sigmaaldrich.cn |
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