| Identification | Back Directory | [Name]
Aramchol | [CAS]
246529-22-6 | [Synonyms]
Aramchol
C20-FABAC
Aramchol (in progress)
(3beta)-Arachidylamido-7alpha,12alpha-dihydroxy-5beta-cholan-24-oic acid
Cholan-24-oic acid, 7,12-dihydroxy-3-[(1-oxoeicosyl)amino]-, (3β,5β,7α,12α)-
(3beta,5beta,7alpha,12alpha)-7,12-Dihydroxy-3-[(1-oxoeicosyl)amino]cholan-24-oic acid
(4R)-4-[(3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-3-(icosanoylamino)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoicacid | [Molecular Formula]
C44H79NO5 | [MDL Number]
MFCD21608618 | [MOL File]
246529-22-6.mol | [Molecular Weight]
702.1 |
| Chemical Properties | Back Directory | [Melting point ]
109-113°C | [Boiling point ]
806.0±65.0 °C(Predicted) | [density ]
1.05±0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
4.76±0.10(Predicted) | [color ]
White |
| Hazard Information | Back Directory | [Uses]
Aramchol is a fatty acid conjugate that exhibits?hypocholesterolemic effects. Studies have shown that aramchol?suppresses the activity of?stearoyl-CoA desaturase (SCD), which leads to reduction of obesity, fatty liver and insulin resistance. | [Biological Activity]
Arachidyl amido cholanoic acid (Aramchol) is a cholesterol solubilizer th at has the potential to prevent and dissolves cholesterol gallstones in inbred mice and in human gallbladder bile ex vivo.''Aramchol is a bile salt fatty acid conjugate (BAFAC) of arachidic acid and cholic acid. It has been shown to reduce liver f at by a dual mechanism of action. It inhibits the activity of liver stearoyl coenzyme A desaturase 1 (SCD1)decreasing the synthesis of fatty acids. In additionit activates cholesterol efflux by stimulating the adenosine triphosphate–binding cassette transporter A1 (ABCA1). Aramchol has been investigated for treatment for nonalcoholic steatohepatitisor NASH. |
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| Company Name: |
Twochem Co.Ltd.
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021-58111628 15800915896 |
| Website: |
cn.twochem.com |
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