| Identification | Back Directory | [Name]
NFAT Transcription Factor Regulator | [CAS]
245747-71-1 | [Synonyms]
NFAT Transcription Factor Regulator
NFAT Transcription Factor Regulator-1
4-Pyridinecarboxamide, N-[4-[5-(difluoromethoxy)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro- | [Molecular Formula]
C17H10F6N4O2 | [MDL Number]
MFCD31715449 | [MOL File]
245747-71-1.mol | [Molecular Weight]
416.28 |
| Chemical Properties | Back Directory | [Boiling point ]
408.4±45.0 °C(Predicted) | [density ]
1.53±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 150 mg/mL (360.33 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
9.85±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
NFAT Transcription Factor Regulator-1 is an inhibitor of IL-2 synthesis with IC50 of 182 nM. | [in vitro]
NFAT Transcription Factor Regulator-1 (compound example 19) inhibits IL-2 synthesis with an IC 50 of 182 nM. NFAT Transcription Factor Regulator-1 inhibits human and rat PBMC proliferation with IC 50 s of 82 and 146 nM, respectively. NFAT Transcription Factor Regulator-1 is able to inhibit IL-4 and IL-5 production in human T-cell lines with similar potency to its effects on IL -2 release. | [target]
| IL-2 < span> 182 nM (IC 50 ) | | [storage]
Store at -20°C |
|
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DC Chemicals
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MedChemExpress
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www.medchemexpress.com |
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