| Identification | Back Directory | [Name]
BPK-29 hydrochloride | [CAS]
2444815-73-8 | [Synonyms]
BPK-29 hcl
BPK-29 hydrochloride
inhibit,BPK 29,BPK29,BPK-29,Inhibitor,BPK 29 hydrochloride,BPK29 hydrochloride | [Molecular Formula]
C26H33Cl2N3O3 | [MOL File]
2444815-73-8.mol | [Molecular Weight]
506.47 |
| Hazard Information | Back Directory | [Description]
BPK-29 hydrochloride is a specific ligand that disrupts the atypical orphan nuclear receptor NR0B1-protein (such RBM45 and SNW1) interactions by covalently modifying C274. BPK-29 hydrochloride impairs the anchorage-independent growth of KEAP1-mutant cancer cells[1]. BPK-29 hydrochloride substantially engages NR0B1 with good overall proteomic selectivity in KEAP1-mutant Non-Small Cell Lung Cancers[1]. | [References]
[1]. Bar-Peled L, et al. Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. Cell. 2017 Oct 19;171(3):696-709.e23. |
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