| Identification | Back Directory | [Name]
2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]- | [CAS]
2443816-45-1 | [Synonyms]
2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]- | [Molecular Formula]
C22H16F4N4OS | [MDL Number]
MFCD31813791 | [MOL File]
2443816-45-1.mol | [Molecular Weight]
460.45 |
| Hazard Information | Back Directory | [Biological Activity]
ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively. | [in vitro]
ULK-101 inhibited the induction of autophagy and autophagic flux under different stimuli. ULK-101 sensitizes KRAS-mutated lung cancer cells to nutrient stress. | [target]
| Target | Value | ULK1
(Cell-free assay) | 8.3 nM | ULK2
(Cell-free assay) | 30 nM |
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DC Chemicals
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https://www.weikeqi-biotech.com/ |
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