| Identification | Back Directory | [Name]
Undecanoic acid, 11-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- | [CAS]
2428400-33-1 | [Synonyms]
Pomalidomide-C10-COOH
Thalidomide-NH-C10-acid
Undecanoic acid, 11-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- | [Molecular Formula]
C24H31N3O6 | [MDL Number]
MFCD34469879 | [MOL File]
2428400-33-1.mol | [Molecular Weight]
457.52 |
| Chemical Properties | Back Directory | [Boiling point ]
718.9±55.0 °C(Predicted) | [density ]
1.303±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.78±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
Thalidomide-NH-C10-COOH (compound 6b) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based von Hippel-Lindau (VHL) ligand and a linker used in PROTAC technology[1]. | [References]
[1]. Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera. Sci Rep. 2019 Dec 23;9(1):19654. |
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