| Chemical Properties | Back Directory | [density ]
1.384±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
14.934±0.46(predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
FGFR1 inhibitor-10 (Compound 4i) is an FGFR1 inhibitor (IC50: 28 nM). FGFR1 inhibitor-10 inhibits the phosphorylation of FGFR1. FGFR1 inhibitor-10 has anti-angiogenic, anti-invasion activity, and anti-tumor effect[1]. | [IC 50]
FGFR1 | [References]
[1] Li YL, et al. Design, synthesis and evaluation of novel pyrimidinylaminothiophene derivatives as FGFR1 inhibitors against human glioblastoma multiforme. Eur J Med Chem. 2023 Nov 15;260:115764. DOI:10.1016/j.ejmech.2023.115764 |
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