| Chemical Properties | Back Directory | [Boiling point ]
661.672±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.510±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
7.848±0.20(predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
BChE-IN-17 (compound 6n) is a potent and selective BChE inhibitor with IC50s of 10.5 nM and 32.5 nM for eqBChE and hBChE, respectively. BChE-IN-17 shows over 1000-fold selectivity to BChE against AChE. BChE-IN-17 shows low neurotoxicity and moderate neuroprotective effects[1]. | [IC 50]
eqBCHE: 10.5 nM (IC50); hBCHE: 32.5 nM (IC50); eel AChE: 686.4 μM (IC50) | [References]
[1] Tingkai Chen, et al. The structural modification and biological evaluation of tetrahydrothienopyridine derivatives as selective BChE inhibitors. Bioorg Med Chem Lett. 2023 Sep 1;93:129436. DOI:10.1016/j.bmcl.2023.129436 |
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