| Identification | Back Directory | [Name]
ZONIPORIDE | [CAS]
241800-98-6 | [Synonyms]
CP 597396
ZONIPORIDE
Zoniporide hydrochloride hydrate
N-carbamimidoyl-5-cyclopropyl-1-(5-quinolyl)pyrazole-4-carboxamide
N-[5-Cyclopropyl-1-(quinolin-5-yl)-1H-pyrazole-4-carbonyl]guanidine
1H-Pyrazole-4-carboxamide, N-(aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-
N-(Aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide hydrochloride hydrate | [Molecular Formula]
C17H16N6O | [MDL Number]
MFCD04113213 | [MOL File]
241800-98-6.mol | [Molecular Weight]
320.35 |
| Chemical Properties | Back Directory | [density ]
1.54 | [storage temp. ]
2-8°C | [solubility ]
H2O: soluble2mg/mL, clear (warmed) | [form ]
powder | [pka]
11.44±0.46(Predicted) | [color ]
white to tan | [Water Solubility ]
H2O: 2mg/mL, clear (warmed) |
| Hazard Information | Back Directory | [Uses]
Zoniporide hydrochloride hydrate has been used for the inhibition of sodium-hydrogen exchanger isoform 1 (NHE-1) in rat models. It has also been used in cytotoxicity assay and to study its effect on lymphocytic choriomeningitis virus multiplication. | [Biochem/physiol Actions]
Zoniporide is a potent and selective inhibitor of Na+/H+ exchanger isoform 1 (NHE-1). IC50 = 59 nM at NHE-1, vs. 12,000 nM at NHE-2; Zoniporide inhibits NHE-1-dependent Na+ update with IC50 of 14 nM. |
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