| Identification | Back Directory | [Name]
3-Thiophenamine, 4-[(4-chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-, 1,1-dioxide, (3R,4S)-rel- | [CAS]
2416095-06-0 | [Synonyms]
CBR-470-1
3-Thiophenamine, 4-[(4-chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-, 1,1-dioxide, (3R,4S)-rel- | [Molecular Formula]
C14H20ClNO4S2 | [MOL File]
2416095-06-0.mol | [Molecular Weight]
365.89 |
| Chemical Properties | Back Directory | [Boiling point ]
592.4±50.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Soluble to 100 mM in DMSO and to 20 mM in ethanol | [form ]
Solid | [pka]
6.28±0.40(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Biological Activity]
CBR-470-1 is an Inhibitor of the glycolytic enzyme PGK1 th at induces Nrf2 activity. PGK1 inhibition results in acculumation of methylglyoxalyl (MGO)a toxicreactive metabolite removed by other enzymes. The accumulated MGO then irreversibly reacts with Keap1 forming inactive Keap1 dimersresulting in accumulation of Nrf2. | [storage]
Store at -20°C |
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