| Identification | Back Directory | [Name]
Nicotinamide riboside malate | [CAS]
2415659-01-5 | [Synonyms]
Nicotinamide riboside malate
Nicotinamide Riboside Hydrogen Malate | [MDL Number]
MFCD34549739 |
| Hazard Information | Back Directory | [Description]
As a NAD+ precursor, Nicotinamide riboside malate increases NAD+ levels in the body. NAD+ plays an important role in physiological processes such as cellular energy metabolism and DNA repair, and its increased levels help support heart, brain and metabolic function. | [Uses]
Nicotinamide riboside malate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2]. | [in vivo]
Chronic Nicotinamide riboside malate (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner[1]. | Animal Model: | 10-week-old C57Bl/6J mice[1] | | Dosage: | 400 mg/kg | | Administration: | PO; daily; for 16 weeks | | Result: | Increased plasma and intracellular NAD+ content in a tissue-specific manner.
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SIRT1; SIRT3; Human Endogenous Metabolite | [References]
[1] Cantó C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47. DOI:10.1016/j.cmet.2012.04.022
[2] Bing Gong, et al. Nicotinamide Riboside Restores Cognition Through an Upregulation of Proliferator-Activated Receptor-γ Coactivator 1α Regulated β-Secretase 1 Degradation and Mitochondrial Gene Expression in Alzheimer's Mouse Models. Neurobiol Aging. 2013 Jun;34(6):1581-8. DOI:10.1016/j.neurobiolaging.2012.12.005
[3] Collin D Heer, et al. Coronavirus and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity. bioRxiv. 2020 Apr 30;2020.04.17.047480. DOI:10.1101/2020.04.17.047480 |
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