| Identification | Back Directory | [Name]
TL02-59 dihydrochloride | [CAS]
2415263-06-6 | [Synonyms]
TL02-59 dihydrochloride
TL0259 dihydrochloride,TL-02-59 dihydrochloride,TL02 59 dihydrochloride | [Molecular Formula]
C32H35ClF3N5O4 | [MDL Number]
MFCD34470292 | [MOL File]
2415263-06-6.mol | [Molecular Weight]
646.11 |
| Hazard Information | Back Directory | [Biological Activity]
TL 0259 is a selective and highly potent Fgr and Lyn inhibitor (IC50 values are 0.03 and 0.1 nM, respectively). Exhibits selectivity for Fgr and Lyn over other Src family kinases and other nonreceptor and receptor tyrosine kinases. Suppresses proliferation of acute myelogenous leukemia (AML) cell lines in vitro. Eliminates leukemic cells from spleen and bone of mice bearing AML xenografts. Orally bioavailable. | [storage]
Store at -20°C |
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