| Identification | Back Directory | [Name]
1-(((2R,3S)-2-(2,5-difluorophenyl)-3-Methyloxiran-2-yl)Methyl)-1H-1,2,4-triazole | [CAS]
241479-73-2 | [Synonyms]
1-(((2R,3S)-2-(2,5-difluorophenyl)-3-Methyloxiran-2-yl)Methy...
1-[2-(2,5-Difluoro-phenyl)-3-methyl-oxiranylmethyl]-1H-[1,2,4]triazole
1H-1,2,4-Triazole,1-[[(2R,3S)-2-(2,5-difluorophenyl)-3-Methyloxiranyl]Methyl]
1-[[(2R,3S)-2-(2,5-Difluorophenyl)-3-methyloxiranyl]methyl]-1H-1,2,4-triazole
(2R,3S)-2-(2,5-DIFUOROPHENYL)-3-METHYL-((1H-1,2,4-TRIAZOL-1- YL)METHYL)OXIRANE
(2r,3s)-2-(2,5-difluorophenyl)-3-methyl-((1h-1,2,4-triazol-1-yl)methyl)oxirane
(2R,3S)-2-(2,5-DIFUOROPHENYL)-3-METHYL-2-((1H-1,2,4-TRIAZOL-1- YL)METHYL)OXIRANE
1-(((2R,3S)-2-(2,5-difluorophenyl)-3-Methyloxiran-2-yl)Methyl)-1H-1,2,4-triazole
1H-1,2,4-Triazole, 1-[[(2R,3S)-2-(2,5-difluorophenyl)-3-methyl-2-oxiranyl]methyl]-
(2R,3S)-2-(2,5-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)-methyl]-oxirane
(2R,3S)-2-(2,5-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)-methyl]-oxirane （2R,3S）-2- | [Molecular Formula]
C12H11F2N3O | [MDL Number]
MFCD30343823 | [MOL File]
241479-73-2.mol | [Molecular Weight]
251.23 |
| Chemical Properties | Back Directory | [Boiling point ]
386.5±52.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [pka]
2.75±0.10(Predicted) | [InChI]
InChI=1S/C12H11F2N3O/c1-8-12(18-8,5-17-7-15-6-16-17)10-4-9(13)2-3-11(10)14/h2-4,6-8H,5H2,1H3/t8-,12+/m0/s1 | [InChIKey]
QYOWWJNQQPRWCO-QPUJVOFHSA-N | [SMILES]
N1(C[C@]2(C3=CC(F)=CC=C3F)[C@H](C)O2)C=NC=N1 |
| Hazard Information | Back Directory | [Chemical Properties]
1-(((2R,3S)-2-(2,5-difluorophenyl)-3-Methyloxiran-2-yl)Methyl)-1H-1,2,4-triazole, also known as (2R,3S)-2-(2,5-Difluorophenyl)-3-methyl-[(1H-1,2,4-triazol-1-yl)methyl]oxirane, is a off white or white powder. | [Preparation]
(2R, 3R)-2-(2,5-Difluoro-phenyl)-1-[1 ,2,4]-triazol-1-yl-butane-2,3-diol (324 mg, 1.20 mmol) is dissolved in methylene chloride (13 ml) and then triethylamine (0.59 ml, 4.2.mmol) is added to the reaction mixture. The reaction mixture is cooled to 0 ℃ and methane sulfonyl chloride (0.21 ml, 2.72 mmol) dissolved in methylene chloride (4 ml) is added. After 4 hours, sodium hydroxide solution (0.98 ml) is added and the reaction mixture is stirred at room temperature overnight. Finally, 1-(((2R,3S)-2-(2,5-difluorophenyl)-3-Methyloxiran-2-yl)Methyl)-1H-1,2,4-triazole was obtained through purification.
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