| Identification | Back Directory | [Name]
4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester | [CAS]
24136-23-0 | [Synonyms]
MBX 102
Arhalofenate
JNJ 39659100
MBX-102 >=98% (HPLC)
4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester
(aR)-4-Chloro-a-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester
Benzeneaceticacid,4-chloro-α-[3-(trifluoromethyl)phenoxy]-,2-(acetylamino)ethylester,(αR)-
Benzeneacetic acid, 4-chloro-α-[3-(trifluoromethyl)phenoxy]-, 2-(acetylamino)ethyl ester, (αR)- | [Molecular Formula]
C19H17ClF3NO4 | [MOL File]
24136-23-0.mol | [Molecular Weight]
415.79 |
| Chemical Properties | Back Directory | [Boiling point ]
551.1±50.0 °C(Predicted) | [density ]
1.331 | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥35mg/mL | [form ]
powder | [pka]
15.32±0.46(Predicted) | [color ]
white to tan |
| Hazard Information | Back Directory | [Uses]
MBX 102 is used as a new medication to treat and prevent acute gouty flares, also used as URAT 1 inhibitor. | [Biological Activity]
MBX-102 has a potent transrepression effect on PPARγ. It is an oral glucose-reducing agent and also has insulin-sensitizing properties. It is useful as treatment for type 2 diabetes. MBX-102 also lowers triglycerides in a PPARα-independent manner.''MBX-102 is a selective PPAR modulator (SPPARM) and has been shown to inhibit phosphorylation of PPARγ. MBX-102 is converted to the active formMBX-102 acidin vivo. | [storage]
Store at -20°C |
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