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ChemicalBook--->CAS DataBase List--->2410598-01-3

2410598-01-3

2410598-01-3 Structure

2410598-01-3 Structure
IdentificationBack Directory
[Name]

Boc-NH-PEG10-CH2CH2COOH
[CAS]

2410598-01-3
[Synonyms]

BocNH-PEG10-COOH
Boc-NH-PEG10-CH2CH2COOH
[Molecular Formula]

C28H55NO14
[MDL Number]

MFCD27635164
[MOL File]

2410598-01-3.mol
[Molecular Weight]

629.74
Chemical PropertiesBack Directory
[Boiling point ]

683.5±55.0 °C(Predicted)
[density ]

1.121±0.06 g/cm3(Predicted)
[pka]

4.28±0.10(Predicted)
Hazard InformationBack Directory
[Biological Activity]

Boc-NH-PEG10-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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