| Identification | Back Directory | [Name]
10-chloro-7H-benzimidazo[2,1-a]benzo[de]isoquinolin-7-one | [CAS]
23982-76-5 | [Synonyms]
10-Cl-BBQ
10-Cl-BBQ >=98% (HPLC)
10-Chloro-7H-benzimidazo[2
1-a]benzo[de]Iso-quinolin-7-one
10-chloro-7H-benzimidazo[2,1-a]benzo[de]isoquinolin-7-one | [Molecular Formula]
C18H9ClN2O | [MDL Number]
MFCD03863624 | [MOL File]
23982-76-5.mol | [Molecular Weight]
304.73 |
| Hazard Information | Back Directory | [Biological Activity]
10-Cl-BBQ is an orally bioavailablenon-toxic benzimidazoisoquinoline derivative th at acts as an aryl hydrocarbon receptor (AhR) agonist via directly binding to AhR (IC50 = 2.6 nM in a competitive binding assay) and induces its nuclear translocation. 10-Cl-BBQ is shown to increase CD4+ T-cells th at co-express CD25CTLA-4 and ICOSas well as several other genes associated with regulatory T cell (Treg) function in a graft versus host response model (GVHC57BI/6 T cells injected into B6D2F1 host mice). 10-Cl-BBQ displays good pharmacokinetic profile in mice (t1/2 = 2 hCmax = 21.5 μg/L10 mg/kgi.p.). Also shown to prevent insulitis in a NOD T1D mouse model which is independent of Fox3 + Tregs (60 mg/kgp.oq.o.d.). | [storage]
Store at +4°C |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
R&D Systems, Inc
|
| Tel: |
18003437475 18003437475 |
| Website: |
www.rndsystems.com |
| Company Name: |
Merck KGaA
|
| Tel: |
(+86) 21 2033 8288 |
| Website: |
http://www.sigmaaldrich.cn |
| Company Name: |
Specs
|
| Tel: |
+31 15 251 8111 |
| Website: |
www.specs.net |
|