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ChemicalBook--->CAS DataBase List--->2389149-74-8

2389149-74-8

2389149-74-8 Structure

2389149-74-8 Structure
IdentificationBack Directory
[Name]

788Succinic acid
[CAS]

2389149-74-8
[Synonyms]

788Succinic acid
TAK788 succinate
Mobocertinib succinate
[Molecular Formula]

C36H45N7O8
[MDL Number]

MFCD32689632
[MOL File]

2389149-74-8.mol
[Molecular Weight]

703.8
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 25 mg/mL (35.52 mM; Need ultrasonic)
[form ]

Solid
[color ]

White to yellow
[InChIKey]

YXYAEUMTJQGKHS-UHFFFAOYSA-N
[SMILES]

C(C(=O)O)CC(=O)O.C(C1=CN=C(NC2C=C(NC(=O)C=C)C(N(C)CCN(C)C)=CC=2OC)N=C1C1=CN(C)C2=CC=CC=C12)(=O)OC(C)C
Hazard InformationBack Directory
[Description]

Mobocertinib (TAK-788) succinate is an orally active and irreversible EGFR/HER2 inhibitor. Mobocertinib succinate potently inhibits oncogenic variants containing activating EGFRex20ins mutations with selectivity over wild-type EGFR. Mobocertinib succinate can be used in NSCLC research.
[Uses]

Mobocertinib is an oral targeted therapy drug[1].Mobocertinib is used to treat a certain type of non-small cell lung cancer (NSCLC) that cannot be removed by surgery and has spread to other parts of the body either during or after treatment with platinum chemotherapy medications.
[Mechanism of action]

Mobocertinib acts to inhibit EGFR exon 20 insertion mutations at a lower concentration than it does on wild-type proteins.
[Side effects]

Diarrhoea, rash, nausea, stomatitis, vomiting, decreased appetite, paronychia, fatigue, dry skin,musculoskeletal pain, increased amylase/lipase/creatinine, and decreased potassium/hemoglobin/magnesium/lymphocytes.
[Synthesis]

Mobocertinib succinate is prepared by the reaction of Isopropyl 2-chloro-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate in the presence of an inert atmosphere.
788Succinic acid
[References]

[1] IMRANMOHD. Discovery, Development, Inventions, and Patent Trends on Mobocertinib Succinate: The First-in-Class Oral Treatment for NSCLC with EGFR Exon 20 Insertions.[J]. Biomedicines, 2021. DOI:10.3390/biomedicines9121938.
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